状況をたずねるときの「どうしたの?」は次のようにいう。
What happened?
What's the matter with you?
What's going on here?
What's the deal?
A: Sorry for my late arrival.
B: What's the matter with you?
what happened to ... で「...(人)に何が起きたの?」という意味になる。
What happened to those people?
あの人たちに何があったの?